A lineage tree-based hidden markov model quantifies cellular heterogeneity and plasticity

HIGHLIGHTS

• who: Farnaz Mohammadi from the University of have published the article: A lineage tree-based hidden Markov model quantifies cellular heterogeneity and plasticity, in the Journal: (JOURNAL)
• what: The authors develop an extensible implementation of tHMMs with a defined interface for integrating diverse types of measurements on cell lineage trees. The model likelihood can be used to estimate the number of distinguishable cell states. information to quantify the specific structure of the phenotypic heterogeneity. Across a diverse array of benchmarking experiments the authors show that the model can derive accurate conclusions from synthetic data with . . .
  

   

  

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