A link between autophagy and the pathophysiology of lrrk2 in parkinson’s disease

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  • who: Patricia Gómez-Suaga and collaborators from the Instituto de Parasitologı́a y Biomedicina (López-Neyra), Consejo Superior de Investigaciones Cientificas (CSIC), Granada, Armilla, Spain have published the article: A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson’s Disease, in the Journal: (JOURNAL) of 19/08/2012
  • future: Similarly both overexpression or knockdown of LRRK2 induce defects in vesicle endocytosis upon depolarization of primary neuronal cultures which may involve interactions of LRRK2 with a series of endocytic proteins apart from rab5b but further studies are needed to determine how LRRK2 . . .

     

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