A liquid-to-solid phase transition of cu/zn superoxide dismutase 1 initiated by oxidation and disease mutation

HIGHLIGHTS

• who: Siyu Gu from the (UNIVERSITY) have published the research: A liquid-to-solid phase transition of Cu/Zn superoxide dismutase 1 initiated by oxidation and disease mutation, in the Journal: (JOURNAL) of April/23,/2022
• what: The authors propose that liquid-liquid phase separation (LLPS) represents a biophysical process that converts soluble SOD1 into aggregated SOD1. The authors demonstrate that SOD1 forms liquid droplets in a crowded environment through LLPS in_vitro.
• how: The confocal microscope results showed that droplets tended to form clusters of condensates after 4 h of oxidation compared with . . .
  

   

  

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