A machine learning algorithm with subclonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity

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• who: Rachel Marty Pyke from the , Stanford University have published the article: A machine learning algorithm with subclonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors design a machine_learning algorithm, Deletion of Allele-Specific HLAs (DASH), to more accurately profile HLA allele-specific LOH by capturing the unique features of the HLA region and demonstrate the limit of detection for subclonal events 2 and low tumor purity using sequencing data mixtures from cell lines. The authors develop an allele-specific digital PCR . . .
  

   

  

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