A maladaptive feedback mechanism between the extracellular matrix and cytoskeleton contributes to hypertrophic cardiomyopathy pathophysiology

HIGHLIGHTS

  • who: Helena M. Viola from the School of Human Sciences, The University of Western Australia, Crawley, WA, Australia, The Australian National University, Canberra, ACT, Australia. , Victor Chang Cardiac Research Institute, Sydney, NSW, Australia. have published the research: A maladaptive feedback mechanism between the extracellular matrix and cytoskeleton contributes to hypertrophic cardiomyopathy pathophysiology, in the Journal: (JOURNAL)
  • what: The authors explore the role of this link in the development of HCM pathophysiology involving the LTCC and mitochondria by creating an in_vitro platform that mimics HCM myocardial stiffness. With this, the authors propose that increased ECM stiffness . . .

     

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