A maladaptive pleural environment suppresses preexisting anti-tumor activity of pleural infiltrating t cells

HIGHLIGHTS

• who: Vera S. Donnenberg and collaborators from the Bose Institute, India Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA have published the research work: A maladaptive pleural environment suppresses preexisting anti-tumor activity of pleural infiltrating T cells, in the Journal: (JOURNAL)
• what: The authors examine immune checkpoint molecule (ICM) expression on pleural T_cells, the secretomes of pleural fluid, pleural infiltrating T_cells (PIT), and ability to activate PIT ex vivo. In this report the authors characterize pleural infiltrating T_cells (PIT) for expression immune checkpoint molecules (ICM) and cytokine/chemokine secretion before . . .
  

   

  

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