A mechanistic pharmacodynamic modeling framework for the assessment and optimization of proteolysis targeting chimeras (protacs)

HIGHLIGHTS

• who: Robin Thomas Ulrich Haid and Andreas Reichel from the AG, Mu00fcllerstrau00dfe, Berlin, Germany have published the research work: A Mechanistic Pharmacodynamic Modeling Framework for the Assessment and Optimization of Proteolysis Targeting Chimeras (PROTACs), in the Journal: Pharmaceutics 2023, 15, x FOR PEER REVIEW of /2023/
• what: The authors aimed to generate a PK/PD modeling framework that is directly applicable for the typical questions in early PROTAC drug discovery. Assuming this process is rapid compared to degradation, the authors propose a direct Emax model to link target modulation to the pharmacodynamic response (PD): (1 . . .
  

   

  

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