A method to assess the clinical significance of unclassified variants in the brca1 and brca2 genes based on cancer family history

HIGHLIGHTS

  • who: Vol and collaborators from the of Clinical Genetics, University Hospital Maastricht, , AZ Maastricht, the Netherlands have published the research: A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2 genes based on cancer family history, in the Journal: (JOURNAL)
  • what: The aim of this study was to identify which is the best combination of clinical parameters that can predict whether a UV is deleterious, to be used for the classification of UVs. This study shows that these developed models are useful to classify UVs in clinical genetic practice. The . . .

     

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