A method to map the interaction network of the nuclear lamina with genetically encoded photo-crosslinkers

HIGHLIGHTS

• who: . and colleagues from the Leipzig University, Germany have published the research work: A method to map the interaction network of the nuclear lamina with genetically encoded photo-crosslinkers, in the Journal: (JOURNAL)
• what: This work provides a basis to investigate lamin-protein interactions in living cells with respect to cell cycle stages, disease-related mutations and environmental conditions.
• how: The authors used the orthogonal EcBPARS/tRNACUA system derived from E. coli TyrRS (Seidel and Coin 2018) to install the photo-activatable crosslinker amino_acid p-benzoylphenylalanine (pBPA) in laminC. The authors obtained very . . .
  

   

  

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