HIGHLIGHTS
- who: Jie Zhang from the (UNIVERSITY) have published the Article: A microbial supply chain for production of the anti-cancer drug vinblastine, in the Journal: (JOURNAL) of 12/04/2021
- what: The authors demonstrate the de novo microbial biosynthesis of vindoline and catharanthine using a highly engineered yeast, and in_vitro chemical coupling to vinblastine. The study showcases a very long biosynthetic pathway refactored into a microbial cell factory, including 30 enzymatic steps beyond the yeast native metabolites geranyl pyrophosphate and tryptophan to catharanthine and vindoline. To mitigate the bottlenecks in strictosidine production, the authors focused . . .
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