HIGHLIGHTS
- who: Marlene Geyer from the (UNIVERSITY) have published the research work: A microfluidic-based PDAC organoid system reveals the impact of hypoxia in response to treatment, in the Journal: (JOURNAL) of 11/01/2023
SUMMARY
Hypoxia induces a metabolic switch from oxidative_phosphorylation to lactate production contributing to acidification of the tumor microenvironment. Hypoxia-induced phenotypic and genotypic changes in PDAC organoids (co-)cultures To further evaluate the crucial genes and pathways affected by different oxygen tension conditions, gene_expression analysis was performed with cells grown under normoxic and hypoxic conditions for 4 days. Subsequent . . .
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