HIGHLIGHTS
- who: Nuzulul Kurniansyah from the (UNIVERSITY) have published the research work: A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: To develop the PRS, the authors propose a new approach for selecting tuning parameters for PRS construction, based on optimizing the coefficient of variation of the effect size estimates of five independent subsets of the training dataset, as well as combination of PRS based on GWAS of multiple BP phenotypes into a single PRS. This approach attempts to avoid overfitting to . . .
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