A murine point mutation of sgpl1 skin is enriched with vγ6 il17-producing cell and revealed with hyperpigmentation after imiquimod treatment

HIGHLIGHTS

• who: Wenyi Yang from the Upstate Medical University, United States have published the research work: A Murine Point Mutation of Sgpl1 Skin Is Enriched With Vu03b36 IL17-Producing Cell and Revealed With Hyperpigmentation After Imiquimod Treatment, in the Journal: (JOURNAL)
• what: In the course of this work, the authors were surprised to discover that mice bearing the C57BL/6-Sgpl1 M467K Gris mutation in the Sgpl1 locus (or Sgpl1 M467K as abbreviation), exhibited an acute severe cutaneous inflammation phenotype under IMQ treatment while also being dramatically longer-lived than the previously reported Sgpl1 knockout mutant . . .
  

   

  

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