HIGHLIGHTS
- who: Noelia Lu00f3pez-Su00e1nchez from the Department of Molecular, Cellular and Developmental Neurobiology, Cajal Institute, Consejo Superior de Investigaciones Cientu00edficas, Eu2011, Madrid, Spain have published the research work: A Mutant Variant of E2F4 Triggers Multifactorial Therapeutic Effects in 5xFAD Mice, in the Journal: (JOURNAL)
- what: The authors show that neuronal expression of E2F4DN in 5xFAD mice potentiates a transcriptional program consistent with the attenuation of the immune response and brain homeostasis. The authors propose E2F4DN-based gene therapy as a promising multifactorial approach against AD. To further explore the effect of E2F4DN on the immune . . .
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