HIGHLIGHTS
- who: Giulia E. Tyzack from the Department University of London, London WC N BG, UK have published the research: A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 24/Nov/1986
- what: By integrating mouse in_vivo and in_vitro models with human iPSC-derived astrocytes, the authors provide direct evidence that EphB1 can induce early astrocytic STAT3 activation via ephrin-B1 signalling. Using patient-specific iPSC-derived astrocytes the authors show that this EphB1-induced pathway is impaired in SOD1-mutant astrocytes . . .
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