A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

HIGHLIGHTS

  • who: Dominik Saul from the (UNIVERSITY) have published the paper: A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues, in the Journal: (JOURNAL) of 23/Nov/2021
  • what: After the authors found that some of the "canonical" SASP markers such as EREG/IL1B and SASP/senescence markers such as ICAM1/CDKN1A showed high concordance in their cell-wise expression patterns, the authors aimed to find surrogate genes for certain low-expressed genes--e_g CDKN2A/p16Ink4a. The authors propose a species-specific co-expression analysis with JUN (Homo sapiens) or Dkk1 . . .

     

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