A new mouse model of post-traumatic joint injury allows to identify the contribution of gli1+ mesenchymal progenitors in arthro brosis and acquired heterotopic endochondral ossi

HIGHLIGHTS

• who: August and collaborators from the University of California, Los Angeles, United States have published the research: A new mouse model of post-traumatic joint injury allows to identify the contribution of Gli1+ mesenchymal progenitors in arthro brosis and acquired heterotopic endochondral ossi, in the Journal: (JOURNAL)
• what: The authors demonstrate that Gli1+ cells undergo proliferative expansion after injury and differentiate into myofibroblasts and osteoblasts in_vivo and thus contribute to both knee arthrofibrosis and acquired HO.
• future: Targeted pharmacological interventions may have the potential to alter the outcome of severe knee joint trauma . . .
  

   

  

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