A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein*

HIGHLIGHTS

• who: Akiko Yamagishi from the role in actin cytoskeleton dynamics, which may additively or synergistically work with the, terminal IMDAmong these ligands, Ena/VASP family proteins have been reported to have actin bundling activity associated with the Ena/VASP homology , domain (30). Recently IRSp, has been shown to bind to neural isoforms of espin (31), a novel parallel actin bundling protein originally identified as a component of the Sertoli cell spermatid ectoplasmic specialization (32). The resultant multidomain actin bundling protein complexes may bundle, actin with increased efficiency or contribute to changes in, actin dynamics. Second, the SH3 . . .
  

   

  

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