HIGHLIGHTS
- who: Vaishnavi Muralikrishnan et al. from the Cell, Molecular and Cancer Biology Graduate Program, Medical Sciences Department, Indiana University have published the article: A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer, in the Journal: (JOURNAL)
- what: The authors demonstrate that aldehyde dehydrogenase 1A1 (ALDH1A1) is essential for the survival of OCSCs. The authors show that 974 inhibits stemness phenotypes in HGSOC cell lines, blocks the expression of putative stemness genes and pathways, reduces OCSC frequency, and delays tumor initiation in_vivo. The authors show that 974 is specific to ALDH1A1 by . . .
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