A novel cocktail therapy based on quintuplet combination of oncolytic herpes simplex virus-2 vectors armed with interleukin-12, interleukin-15, gm-csf, pd1v, and il-7 × ccl19 results in enhanced antitumor efficacy

HIGHLIGHTS

• who: Han Hu from the constructed from B , integrated with the HSV receptor and kept in our lab [16]Vero, B R, B, and , cells were cultured with a DME/, medium containing , % fetal bovine serum (FBS). , and , were incubated with medium , containing , % FBS. The cells mentioned above were incubated in the, u00b0C, % , incubator. Six-week-old female Balb/c mice were purchased from Hubei Center for Disease Control and Prevention (Hubei, China). The animals were raised in a specific pathogenfree (SPF) environment. All animal experiments were approved by the Animal Ethics Committee of Hubei University of Technology . . .
  

   

  

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