A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathway*

HIGHLIGHTS

  • who: Dieter Adam from the (UNIVERSITY) have published the research: A Novel Cytoplasmic Domain of the p55 Tumor Necrosis Factor Receptor Initiates the Neutral Sphingomyelinase Pathway*, in the Journal: (JOURNAL) of February/20,/1996
  • what: By analysis of a set of TR55 deletion mutants stably expressed in murine 70Z/3 pre-B cells, the authors show that the N-SMase activation domain (NSD) consists of a cytoplasmic region of the receptor that comprises only 11 amino_acids directly adjacent to the N terminus of the death domain.
  • how: When the transfectants were tested for . . .

     

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