A novel e-cadherin/sox9 axis regulates cancer stem cells in multiple myeloma by activating akt and mapk pathways

HIGHLIGHTS

  • who: Parinya Samart from the (UNIVERSITY) have published the Article: A novel E-cadherin/SOX9 axis regulates cancer stem cells in multiple myeloma by activating Akt and MAPK pathways, in the Journal: (JOURNAL)
  • what: The authors show that depletion of E-cadherin in MM cells remarkably inhibited cell proliferation and cell cycle progression in part through the decreased prosurvival CD138 and Bcl-2 and the inactivated Akt and CSC features including the ability of the cells to form clonogenic colonies indicative of self-renewal and side population were greatly suppressed upon the depletion of E . . .

     

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