A novel nuclear receptor subfamily enlightens the origin of heterodimerization

HIGHLIGHTS

• who: Brice Beinsteiner from the Centre National de la Recherche Scientifique (CNRS) UMR, Illkirch, France have published the research work: A novel nuclear receptor subfamily enlightens the origin of heterodimerization, in the Journal: (JOURNAL)
• what: The authors focused on NR7 of the cephalochordate amphioxus B. lanceolatum. The authors propose that DNA-dependent heterodimerization was an intermediary step instrumental for the later establishment of the full combinatorial ability of NRs through RXR DNA-independent heterodimerization. The authors propose that the functional feature underlying this paradigm is the DNA-dependency for heterodimer formation. The studies combing experimental . . .
  

   

  

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