HIGHLIGHTS
- who: Ferran Araujo-Ayala from the (UNIVERSITY) have published the research work: A novel patient-derived 3D model recapitulates mantle cell lymphoma lymph node signaling, immune profile and in vivo ibrutinib responses, in the Journal: (JOURNAL) of 13/03/2023
- what: The authors aimed to develop a novel 3D spheroid-based model to culture MCL primary cells together with autologous T_cells and healthy donor monocytes, recreating the immune TME. In this context the authors propose the combination with the anti-PD1 mAb nivolumab specifically for those patients with limited ibrutinib responses.
SUMMARY
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