HIGHLIGHTS
- What: To date, however, no studies have examined alternative splicing in CNS tissue at patient lesion sites during MS. To address this, the authors focused the attention on the immunoproteasome gene PSMB8. The authors identified a novel PSMB8 splice variant preferentially upregulated in demyelinated WMLs . The authors show here that EDC4, a marker for NMD and a proxy for aberrant splicing, is highly upregulated in MS WMLs, frequently occurring in GFAP+ astrocytes, though other cells also show high levels of EDC4 expression.
- Who: Benjamin C. Shaw and Jessica L. Williams from the University of Alabama . . .
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