HIGHLIGHTS
SUMMARY
Which results in cell swelling and osmotic lysis (Liu et_al, 2016; Fang et_al, 2020). In the noncanonical pathway, bacterialderived lipopolysaccharide (LPS) recognizes and activates caspase-4/5/11 to induce pyroptosis by cleaving GSDMD (Khanova et_al, 2018; Rathinam et_al, 2019). The new-found pathway is achieved by the cleavage of gasderminE (GSDME), which depends on the activation and participation of caspase-3 (Rogers et_al, 2017; Wang et_al, 2017). Pyroptosis appears to play a significant role in tumor progression and is linked to proliferation, migration, cell cycle, and treatment resistance in various of cancers, according . . .
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