A novel subgroup of uchl1-related cancers is associated with genomic instability and sensitivity to dna-damaging treatment

HIGHLIGHTS

• who: Sebastian Burkart et al. from the University Hospital Heidelberg, Heidelberg, Germany have published the research: A Novel Subgroup of UCHL1-Related Cancers Is Associated with Genomic Instability and Sensitivity to DNA-Damaging Treatment, in the Journal: (JOURNAL) of 25/Dec/2022
• what: The authors demonstrated a prominent UCHL1 expression in cancer cells for a substantial amount of primary HNSC at transcript and protein levels. The authors demonstrate global DNA hypomethylation as one mechanism which causes UCHL1 promoter hypomethylation, and consequently, UCHL1 upregulation. The study elucidated a novel molecularly-defined subgroup of UCHL1related cancers across . . .
  

   

  

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