A novel subtype based on driver methylation–transcription in lung adenocarcinoma

HIGHLIGHTS

• What: In the analysis , the authors aimed to find the DMGs of LUAD and used MethSig and MethylMix methods (Pan et_al 2021; Cedoz et_al 2018). In this study, silhouette coefficient was calculated to compare the clustering performance with information of multi-omics and single-omics. The authors assessed EMT gene signature, including 25 epithelial and 52 mesenchymal marker genes (Chen et_al 2021; Mak et_al 2016). In the analysis , the mutation and cooccurring mutation of EGFR, STK11, TP53 and KRAS were compared among subtypes.
• Who: Xin Wang from the Chinese Academy of Medical Sciences, Beijing, China . . .
  

   

  

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