A novel zap-70 dependent fret based biosensor reveals kinase activity at both the immunological synapse and the antisynapse

HIGHLIGHTS

• who: Clotilde Randriamampita et al. from the CNRS, UMR6102, Marseille, France have published the article: A Novel ZAP-70 Dependent FRET Based Biosensor Reveals Kinase Activity at both the Immunological Synapse and the Antisynapse, in the Journal: (JOURNAL)
• what: The authors report the use of ROZA expressing cells to directly visualize ZAP-70 dependent phosphorylation in T-cell lines and primary human lymphocytes with subcellular resolution during the formation of an immunological synapse. Similarly, the authors propose that in T-cells, the initial synaptic contact may trigger the production of an auto-catalytic activating element . . .
  

   

  

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