A pan-tissue dna-methylation epigenetic clock based on deep learning

HIGHLIGHTS

  • who: Lucas Paulo de Lima Camillo from the (UNIVERSITY) have published the research work: A pan-tissue DNA-methylation epigenetic clock based on deep learning, in the Journal: (JOURNAL) of 17/09/2021
  • what: The authors show that deep learning can improve both the performance and interpretation over the widely used ElasticNet-based models and present AltumAge as a useful tool for age prediction. Next, the authors aimed to determine whether the model type, i.e., a linear regression vs. a neural_network, would significantly impact the performance. Through SHAP, the authors show that AltumAge can . . .

     

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