HIGHLIGHTS
- who: . et al. from the University of Catania, Italy have published the research work: A PDE10A inhibitor CPL500036 is a novel agent modulating striatal function devoid of most neuroleptic side-effects, in the Journal: (JOURNAL)
- what: The authors aimed to evaluate the selectivity against common and pharmacologically relevant off-targets, cytotoxicity, genotoxicity, pharmacokinetics and potential adverse effects of CPL500036 (including catalepsy, metabolic syndrome, hyperprolactinemia, and cardiotoxicity).
- how: The study was carried out in 40 male Wistar Han rats (~10 weeks Tri-City Academic Laboratory Animal Centre Research and Services Centre Medical University of . . .
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