A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes

HIGHLIGHTS

• who: Daniel E. Coral from the External validation in BioVU We sought replication of the discoveries outlined above in an independent European-ancestry cohort from BioVU, a de-identified collection of electronic health records and a linked biobank including inpatient and outpatient data from Vanderbilt University Medical Center (VUMC), a tertiary-care centre in Nashville, Tennessee, USA24- We constructed separate genetic risk score (GRS) coefficients for concordant and discordant profiles and assessed their association with multiple phenotypes (Fig. , and Supplementary Table, ). We first confirmed that the concordant and discordant GRSs were associated with higher obesity risk, respectively . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.