HIGHLIGHTS
- who: Fatima Zahra Marok et al. from the Clinical Pharmacy, Saarland University, Saarbruecken, Germany have published the article: A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug-DrugInteraction Perpetrators, in the Journal: Pharmaceutics 2023, 679 of /2023/
- how: Interaction partner models were selected if (i) the FDA listed them as sensitive or moderately sensitive substrates for CYP3A4 and P-gp (ii) the evaluation as CYP3A4 and P-gp victim models was thoroughly investigated in DDI networks (iii) models were developed in the Open System Pharmacology Suite and_(iv) model files were publicly . . .
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