HIGHLIGHTS
- who: Joshua D. Ooi from the Monash University, Clayton, VIC, Australia have published the research: A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors demonstrate that molecular mimicry mechanistically contributes to the loss of tolerance to MPO in AAV. The authors evaluate whether microbial-derived peptides, including those from S. aureus, with sequence homology to the immunodominant MPO CD4+ T-cell epitope can induce the expansion of naive CD4+ T_cells that recognize MPO, with the subsequent development of cross-reactive anti-MPO . . .
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