A point mutation in gαo and gαi1blocks interaction with regulator of g protein signaling proteins*

HIGHLIGHTS

• who: Keng-Li Lan from the effect of the G , S mutation is both specific in that it only disrupts RGS binding and quite general in the range of a subunit and RGS proteins that it effectsThe introduction of this mutation into G protein a subunits can be used in conjunction with expression or transgenic animal studies to evaluate the physiological role of endogenous RGS proteins in the function of a given G protein. Acknowledgments-The authors thank Dr. Albrecht Moritz for providing the GST-, expression construct and Masakatsu Nanamori for expression and purification of the ao . . .
  

   

  

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