A pold3/blm dependent pathway handles dsbs in transcribed chromatin upon excessive rna:dna hybrid accumulation

HIGHLIGHTS

• who: S. Cohen from the CNRS have published the article: A POLD3/BLM dependent pathway handles DSBs in transcribed chromatin upon excessive RNA:DNA hybrid accumulation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: Since both POLD3 and BLM were previously involved in BIR at telomeres in ALT_cells49,50,52, the authors focused on the occurrence of copy number alteration, especially tandem duplication (TD) below 100 kb, previously associated to BIR62. The authors show that BLM preferentially associates with DSBs located in active transcription units, where it fosters resection and RAD51 assembly. The authors show . . .
  

   

  

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