A potential defensive role of tim-3 on t lymphocytes in the inflammatory involvement of diabetic kidney disease

HIGHLIGHTS

  • What: This study investigated the expression of immune checkpoint molecules on T lymphocytes in peripheral blood and kidney tissue, and analyzed their relationship with clinical parameters and renal pathology in DKD patients. This study analyzed a cohort of 360 DKD patients, and the results are presented in Table 1. The research has Gene expression of Tim-3 and its ligands in DKD mouse model The research has revealed that patients with diabetes who have developed DR, DPN, or other glomerular nephropathy exhibit down-regulation of LAG-3 on peripheral T lymphocyte compared to controls.
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