A practical guide for mutational signature analysis in hematological malignancies

HIGHLIGHTS

• who: Francesco Maura from the Department University of, Boston , MA, USA have published the research work: A practical guide for mutational signature analysis in hematological malignancies, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: Here the authors report the first case of APOBEC-mediated kataegis in a therapy-related AML case, again associated with a complex rearrangement (Fig 5d-f). To obviate this problem, the authors propose two approaches. The authors explored caveats and pitfalls of mutational signature analysis using whole-genome sequencing data from three common hematological neoplasms, focusing on the sample set preparation . . .
  

   

  

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