A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome

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• who: Hu00e9lu00e9na Boutzen from the (UNIVERSITY) have published the article: A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome, in the Journal: (JOURNAL) of 21/09/2022
• what: The authors report the development of a patient-derived primary AML model, called OCI-AML22, that reflects the functional, transcriptional and epigenetic cellular hierarchy common to most primary AML samples, providing a powerful resource that permits investigation of the molecular basis of the stemness in LSC. Similarly, using chromatin accessibility signatures generated from highly purified . . .
  

   

  

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