A pyridinesulfonamide derivative fd268 suppresses cell proliferation and induces apoptosis via inhibiting pi3k pathway in acute myeloid leukemia

HIGHLIGHTS

• who: Yi Chen et al. from the Fudan University, Shanghai, China, Institute of Metabolism and Integrative Biology, Fudan University, and have published the research: A pyridinesulfonamide derivative FD268 suppresses cell proliferation and induces apoptosis via inhibiting PI3K pathway in acute myeloid leukemia, in the Journal: PLOS ONE of November/22,/2022
• what: The authors demonstrated that dose-dependently inhibits survival of AML cells with the efficacy superior to that of PI-103 (pan-PI3K inhibitor) and CAL-101 (selective PI3Ku03b4 inhibitor) in the tested HL-60 MOLM-16 Mv-4-11 EOL-1 and KG . . .
  

   

  

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