HIGHLIGHTS
SUMMARY
IFNs activate nitric oxide synthase and several other pathways (Samuel, 2001; Lamers et_al, 2019). Trefoil factor 2 (TFF2) is a secreted polypeptide, that is, resistant to acid, heat, and protease hydrolysis and can protect the gastrointestinal tract and respiratory tract from microbial injury by promoting the repair of injury and regulating the immune_response (Poulsen et_al, 1999) (Baus-Loncar et_al, 2005) (Farrell et_al, 2002). The authors have previously tested this concept in SARS-CoV-2 infected patients during the first wave of the COVID-19 outbreak in 2020, and the results showed that the combination . . .
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