A rasgap sh3 peptide aptamer inhibits rasgap-aurora interaction and induces caspase-independent tumor cell death

HIGHLIGHTS

• who: A RasGAP SH and colleagues from the Université Paris Descartes, Hôpital Necker, CNRS UMR, Paris, France, UMR CNRS, Institut Curie, Paris, France have published the research work: A RasGAP SH3 Peptide Aptamer Inhibits RasGAP-Aurora Interaction and Induces Caspase-Independent Tumor Cell Death, in the Journal: (JOURNAL)
• what: The authors report the selection and characterization of peptide aptamers that bind specifically to RasGAP SH3.
• how: The authors examined the biological activity of targeting pocket delineated by residues D295/7 L313 and W317. The results are in line with the recent observation . . .
  

   

  

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