HIGHLIGHTS
SUMMARY
The symmetry postulate of MWC required that tertiary conformational changes are only associated with the change in quaternary_structure. The tertiary two-state (TTS) model that I am about to describe incorporates the SK notion of two tertiary conformations within each quaternary_structure, the difference being that two tertiary conformations can exist with and without oxygen bound, so four tertiary conformations can co-exist within each quaternary_structure. scitation.org/journal/jcp The TTS model represents the simplest possible way of extending the MWC model to include tertiary conformational changes upon oxygen binding without a change in . . .
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