A reversible mitochondrial complex i thiol switch mediates hypoxic avoidance behavior in c. elegans

HIGHLIGHTS

• who: John O. Onukwufor from the University of Rochester Medical Center, Rochester, NY, USA have published the paper: A reversible mitochondrial complex I thiol switch mediates hypoxic avoidance behavior in C. elegans, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors report that mitochondrial complex I senses hypoxia and induces avoidance behaviors through the oxidation of a single cysteine residue in the NDUF-2.1 subunit. While overproduction of complex I ROS is widely associated with hypoxic pathology, the authors demonstrate that site-specific ROS production instead results in a selective, physiologic pro-survival . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.