HIGHLIGHTS
SUMMARY
Treatment of localized disease usually involves a combination of multi-agent chemotherapy, radiation therapy, and surgery. Improvements in chemotherapy and radiation therapy have increased the proportion of patients with non-metastatic disease who can undergo surgery. Given that the duodenum is resected during Whipple surgery, intraoperative radiation therapy (IORT) provides a unique opportunity to intensify radiation delivery for pancreatic cancer and further escalate the radiation dose delivered beyond what is feasible with external beam radiation therapy alone, even with modern technologies such as stereotactic body radiation therapy (SBRT). Several studies have investigated the role . . .
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