A self-immolative linker for the ph-responsive release of amides

HIGHLIGHTS

  • who: Agnese Petrini and collaborators from the Dipartimento di Biotecnologie, Chimica e Farmacia Universitu00e0 di Siena, Via AMoro, Siena, Italy have published the research: A Self-Immolative Linker for the pH-Responsive Release of Amides, in the Journal: Molecules 2023, 2445 of /2023/
  • what: The authors report a general procedure for the preparation of benzylic N-acyl carbamates suitable for masking the amide group in important drugs such as Linezolid Enzalutamide or Tasimelteon in good to acceptable yields.
  • how: Unfortunately acetylation of the resulting carbamate Better results were obtained by carbamoylation of amine . . .

     

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