A senescence stress secretome is a hallmark of therapy-related myeloid neoplasm stromal tissue occurring soon after cytotoxic exposure

HIGHLIGHTS

  • who: Monika M. Kutyna from the (UNIVERSITY) have published the paper: A senescence stress secretome is a hallmark of therapy-related myeloid neoplasm stromal tissue occurring soon after cytotoxic exposure, in the Journal: (JOURNAL) of 16/Dec/2021
  • what: One limitation of the study is that the serial BMSC studies (Fig 8), while convincingly show evidence of time-dependent causality before and after exposure to CT, were obtained exclusively from patients with multiple myeloma. The study provides comprehensive phenotypic, functional, and molecular profiling of tMN BMSC compared to carefully curated samples from pMN, pMN+Ca . . .

     

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