A setmelanotide-like effect at mc4r is achieved by mc4r dimer separation

HIGHLIGHTS

• who: Nanina Reininghaus et al. from the , Berlin, Germany have published the article: A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation, in the Journal: Biomolecules 2022, 1119 of /2022/
• what: The authors analyzed effects of inhibiting homodimerization on Gq/11 signaling using previously reported MC4R/CB1R chimeras. The study shows that inhibiting homodimerization has a setmelanotide-like effect on Gq/11 signaling with chimeric receptors presenting increased potency compared to MC4RWT. The aim of this study was to investigate if homodimer separation of the MC4R also has an effect on G . . .
  

   

  

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