HIGHLIGHTS
SUMMARY
Encapsulation of the implanted probes, resulting in dysfunction of the devices10. The assembly of the optical fiber and electrode(s) generally results in a significant increase in the volume of the implant5, which produces additional tissue damage. Third, existing optical waveguide materials, such as polycarbonate (e_g, 2-2.4 GPa) and quartz (e_g, 77-85 GPa), have a Young`s modulus far greater than that of brain tissue (e_g, 1-10 kPa)21. The authors present an optoelectronic probe, Silk-Optrode, with natural silk as an optical waveguide material, which can simultaneously achieve high . . .
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