A single 2′-o-methylation of ribosomal rna gates assembly of a functional ribosome

HIGHLIGHTS

  • who: James N. Yelland from the (UNIVERSITY) have published the research: A single 2u2032-O-methylation of ribosomal RNA gates assembly of a functional ribosome, in the Journal: (JOURNAL) of 19/Dec/2022
  • what: The authors show that methylation of a single nucleotide, in the catalytic center of the large subunit, gates ribosome assembly. This work shows that a single RNA modification is a critical checkpoint in ribosome biogenesis, suggesting that such modifications can play an important role in regulation and assembly of macromolecular machines.
  • future: Future work will address the biochemical consequences . . .

     

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